Dr. Alter’s work focuses on the development of systems biology tools to define the humoral  correlates of immunity against infectious diseases. These efforts include the development of “Systems Serology” – a humoral profiling approach which enables her to comprehensively dissect the immune response. This novel antibody-OMIC platforms enables the dissection of pathogen- or vaccine-specific humoral immune responses at an unprecedented depth. Coupled to machine learning and artificial intelligence, her work unveils the mechanistic basis of protective immunity across pathogens, often pointing to unexpected correlates of humoral immunity against infection.