The ”Disruptive Dozen” results from interviews of one hundred Mass General Brigham senior Harvard faculty followed by a rigorous selection process to identify the twelve mostly likely to have significant impact on healthcare.View Playlist
Type 1 diabetes is a chronic illness that results when the body’s own immune system attacks the insulin-producing cells in the pancreas, destroying the cells and creating a life-long dependence on exogenous insulin. Although insulin replacement is an effective treatment, it is not a cure. A newly approved drug that targets a critical protein on T-cells, deactivating them and thwarting their destruction of insulin-producing cells, has been shown to delay the onset of type 1 diabetes in children and young adults at high risk for the disease.
Researchers are working develop a simple, cost-effective way to diagnose Alzheimer’s disease and other neurodegenerative conditions decades before the onset of physical symptoms — when the course of the disease could potentially be halted or perhaps even reversed. Such a diagnostic test could rapidly accelerate the development of effective treatments for these diseases, and also form a key piece of the puzzle for lowering the future public health burden of Alzheimer’s disease, which is projected to skyrocket by 2050.