Past Forum 2022

First Look: 8 rapid fire presentations on Mass General Brigham’s new GCT technologies

• • Moderator: Meredith Fisher, PhD, Partner, Mass General Brigham Ventures
  • Moderator: Roger Kitterman, VP, Mass General Brigham Ventures

  Presenters:

  • Bakhos Tannous, PhD, Director, Experimental Therapeutics Unit, Director, Viral Vector Core, MGH; Professor of Neurology, HMS
  • Vijaya Ramesh, PhD, Co-Director of Neuroscience, Associate Geneticist in Neurology, MGH; Professor of Neurology, HMS
  • Anna Krichevsky, PhD, Associate Professor of Neurology, BWH, HMS
  • Nerea Zabaleta, PhD, Principal Investigator, Grousbeck Gene Therapy Center, Mass Eye and Ear; Instructor in Ophthalmology, HMS
  • Francisco Quintana, PhD, Professor, Neurology, Ann Romney Center for Neurologic Diseases, BWH; Kuchroo Weiner Distinguished Professor of Neuroimmunology, BWH
  • Stephen Haggarty, PhD, Director, Chemical Neurobiology Laboratory, Center for Genomic Medicine, MGH; Associate Professor of Neurology, HMS
  • Michael Young, PhD, Director, Minda de Gunzburg Center for Retinal Regeneration, Associate Scientist, Schepens Eye Research Institute, Mass Eye and Ear; Associate Professor of Ophthalmology, Co-Director, Ocular Regenerative Medicine Institute, HMS
  • Max Jan, MD, PhD, Principal Investigator, Center for Cancer Research, MGH; Assistant Professor of Pathology, HMS

First Look: 8 rapid fire presentations on Mass General Brigham’s new GCT technologies

• • Moderator: Meredith Fisher, PhD, Partner, Mass General Brigham Ventures
  • Moderator: Roger Kitterman, VP, Mass General Brigham Ventures

  Presenters:

  • Choi-Fong Cho, PhD, Assistant Professor of Neurosurgery, BWH, HMS
  • Yulia Grishchuk, PhD, Assistant Investigator, Center for Genomic Medicine, MGH; Assistant Professor of Neurology, HMS
  • Lynn Bry, MD, PhD, Director, Massachusetts Host-Microbiome Center, BWH; Associate Professor of Pathology, HMS
  • David Corey, PhD, Bertarelli Professor of Translational Medical Science, Neurobiology, HMS
  • Anil Chandraker, MD, Medical Director of Kidney and Pancreas Transplantation, BWH; Associate Professor of Medicine, HMS
  • Ole Isacson, MD, PhD, Director, Neuroregeneration Research Institute, McLean; Professor of Neurology & Neuroscience, HMS
  • Marco Mineo, PhD, Instructor in Neurosurgery, BWH, HMS
  • Susan Cotman, PhD, Assistant in Neuroscience, Center for Genomic Medicine, MGH; Assistant Professor of Neurology, HMS

THE DR. IS IN | Gene and Epigenetic Editing in the Development of Treatment for Deafness

• Moderator: Geoff Meacham, PhD, Managing Director, Global Research, BofA Securities
• Albert Edge, PhD, Eaton Peabody Professor of Otolaryngology, HMS, Mass Eye and Ear

THE DR. IS IN | Single Gene Correction in the Brain: Delivering Where it Matters Most

• Moderator: Tazeen Ahmad, Managing Director, Global Research, BofA Securities
• Florian Eichler, MD, Director, Center for Rare Neurological Diseases, MGH; Associate Professor of Neurology, HMS

THE DR. IS IN | Repair, Replace, Regrow: The Advancement of Regenerative Medicine

• Moderator: Jason Zemansky, PhD, Vice President, Global Research, BofA Securities
• Joseph Bonventre, MD, PhD, Chief, Division of Renal Medicine, BWH; Samuel A. Levine Distinguished Professor of Medicine and Constantine L. Hampers Distinguished Chair, HMS
• David Scadden, MD, Director, Center for Regenerative Medicine, MGH; Gerald and Darlene Jordan Professor of Medicine, HMS

THE DR. IS IN | Smart Materials: Non-viral Vectors for Gene Therapy

• Moderator: Alec Stranahan, PhD, Vice President, Equity Research, BofA Securities
• Natalie Artzi, PhD, Assistant Professor of Medicine, HMS

THE DR. IS IN | Newborn Sequencing and Prevention of Rare Diseases: A New Public Health and Biopharma Challenge

• Moderator: Jason Gerberry, Managing Director, Global Research, BofA Securities
• Robert Green, MD, Director, Genomes2People Research Program, BWH; Professor of Medicine, HMS
• Adam Shaywitz, MD, PhD, CMO, BridgeBio Gene Therapy

THE DR. IS IN | Leveraging Novel Mechanisms for Accelerated Vaccine and Immunotherapy Development

• Moderator: Alexandria Hammond, PhD, Associate, Global Research, BofA Securities
• Mark Poznansky, MD, PhD, Director, Vaccine and Immunotherapy Center, MGH; Professor of Medicine, HMS

Opening Remarks

• Introducer: Scott Sperling, Co-Chief Executive Officer, Thomas H. Lee Partners; Chairman of the Board of Directors, Mass General Brigham
• Anne Klibanski, MD, President & CEO, Mass General Brigham; Laurie Carrol Guthart Professor of Medicine, HMS
• Brian Moynihan, Chair & CEO, Bank of America

Co-Chair Kick Off

• Moderator: Susan Hockfield, PhD, President Emerita, MIT
• Miceal Chamberlain, President of Massachusetts, Northeast Region Executive, Bank of America
• Marcela Maus, MD, PhD, Director, Cellular Immunotherapy Program, Cancer Center, MGH; Associate Professor, Medicine, HMS
• Geoff Meacham, PhD, Managing Director, Global Research, BofA Securities
• Ravi Thadhani, MD, Chief Academic Officer, Mass General Brigham

GCT’s Historic Potential | Priorities and Trade Offs

• Moderator: Jean-François Formela, MD, Partner, Atlas Venture
• Pablo Cagnoni, MD, CEO, Rubius Therapeutics
• Kristen Hege, MD, Senior Vice President, Early Clinical Development, Hematology/Oncology & Cell Therapy, Bristol Myers Squibb
• Andrew Plump, MD, PhD, President, R&D, Takeda
  Catherine Stehman-Breen, MD, CEO, Chroma Medicine

Manufacturing | Process Control

• Moderator: John Bishai, PhD, Managing Director, Global Investment Banking, BofA Securities
• Christopher Murphy, Vice President Viral Vector Services, Thermo Fisher
• Michael Paglia, COO, ElevateBio BaseCamp, ElevateBio
• Rahul Singhvi, ScD, CEO, National Resilience, Inc.
• Ran Zheng, CEO, Landmark Bio

FIRESIDE | Regulatory Perspectives on Gene and Cell Therapy: Past Lessons, Current Challenges, Future Directions

• Moderator: Luk Vandenberghe, PhD, Grousbeck Associate Professor in Gene Therapy, Mass General Brigham
  Peter Marks, MD, PhD, Director, Center for Biologics Evaluation and Research, FDA

Clinical GCT Trial Design | Regulatory | Strategy, Innovation and Future Direction | Risk vs Hype

• Moderator: Angela Shen, MD, Vice President, Strategic Innovation Leaders, Mass General Brigham Innovation
• Laura Aguilar, MD, PhD, Co-Founder, Candel Therapeutics
• Matthew Frigault, MD, Clinical Director, Cellular Immunotherapy Program, MGH; Assistant Professor of Medicine, HMS
• Arati Rao, MD, Senior Vice President, Clinical Development, PACT Pharma
• John Rossi, VP Head of Translational Medicine, Syncopation Life Sciences

FIRESIDE | mRNA Opportunities: Lessons Learned, Priorities, and the Future of GCT

• Moderator: Geoff Meacham, PhD, Managing Director, Global Research, BofA Securities
• Albert Bourla, PhD, CEO, Pfizer Inc.

FIRESIDE | Robert Califf, MD, Commissioner Food and Drugs, FDA

• Moderator: Tazeen Ahmad, Managing Director, Global Research, BofA Securities
• Moderator: J. Keith Joung, MD, PhD, Robert B. Colvin, M.D. Endowed Chair in Pathology & Pathologist, MGH; Professor of Pathology, HMS
• Robert Califf, MD, Commissioner of Food and Drugs, US Food and Drug Administration

The Grand Challenge of Widespread GCT Patient Benefits

• Moderator: Susan Hockfield, PhD, President Emerita and Professor of Neuroscience, MIT
• Nino Chiocca, MD, PhD, Neurosurgeon-in-Chief and Chairman, Neurosurgery, BWH; Harvey W. Cushing Professor of Neurosurgery, HMS
• Susan Slaugenhaupt, PhD, Scientific Director and Elizabeth G. Riley and Daniel E. Smith Jr., Endowed Chair, Mass General Research Institute; Professor, Neurology, HMS
• Ravi Thadhani, MD, CAO, Mass General Brigham; Professor, Medicine and Faculty Dean, HMS
• Luk Vandenberghe, PhD, Grousbeck Family Chair, Gene Therapy; MEE Associate Professor, Ophthalmology, HMS

Living with COVID | Lessons Learned and Looking Ahead

• Introducer: Jonathan Kraft, President, The Kraft Group; Chairman of the Board of Trustees, MGH
• Moderator: David Brown, MD, President, Massachusetts General Hospital; Executive Vice President, Mass General Brigham
• Paul Biddinger, MD, Chief Preparedness and Continuity Officer, Mass General Brigham; Associate Professor of Emergency Medicine, HMS
• Helen Branswell, Senior Writer, STAT
• Daniel Kuritzkes, MD, Chief, Division of Infectious Diseases, BWH; Harriet Ryan Albee Professor of Medicine, HMS
• Erica Shenoy, MD, PhD, Associate Chief, Infection Control Unit, MGH; Associate Professor of Medicine, HMS

The Global Biotech Epicenter | New England Now and in 2030

• Moderator: Anne Finucane, Chairman of the Board, Bank of America Europe
• Seth Ettenberg, PhD, President & CEO, BlueRock Therapeutics
• Joel Marcus, Executive Chairman & Founder, Alexandria Real Estate Equities, Inc.
• Terry McGuire, Founding Partner, Polaris Partners
• Vicki Sato, PhD, Chairman of the Board, Vir Biotechnology; Chairman, Denali Therapeutics
• Phillip Sharp, PhD, Institute Professor and Professor of Biology, Koch Institute for Integrative Cancer Research at MIT; Co-Founder, Alnylam Pharmaceuticals, Inc.

The Patient Experience

• Moderator: Merit Cudkowicz, MD, Chair, Dept of Neurology, MGH; Julieanne Dorn Professor of Neurology, HMS
• James Beck, PhD, CSO, Parkinson’s Foundation
• Monica Coenraads, CEO, Rett Syndrome Research Trust
• Annie Ganot, VP, Head of Patient Advocacy, Solid Biosciences
• Staci Kallish, DO, President, Board of Directors, National Tay Sachs and Allied Diseases; Medical Geneticist, Associate Professor of Clinical Medicine, Penn Medicine
• Rebecca Oberman, PhD, Executive Director, Mucolipidosis Type IV (ML4) Foundation

FIRESIDE | Meeting the Moment: The Next Wave of Innovation in Cancer and Cardiology

• Moderator: Geoff Meacham, PhD, Managing Director, Global Research, BofA Securities
• Robert Bradway, CEO, Amgen

First Look Award Presentation

• Presenter: Miceal Chamberlain, President of Massachusetts, Northeast Region Executive, Bank of America
• Presenter: Nino Chiocca, MD, PhD, Neurosurgeon-in-Chief and Chairman, Neurosurgery, BWH; Harvey W. Cushing Professor of Neurosurgery, HMS

IDG Award Announcement

THE DR. IS IN | Personalizing Cancer Care through RNA Therapies

• Moderator: Jason Gerberry, Managing Director, Global Research, BofA Securities
• Pierpaolo Peruzzi, MD, PhD, Neurosurgeon and Principal Investigator, BWH; Assistant Professor of Neurosurgery, HMS

THE DR. IS IN | Designing for Success: Clinical Trial Approaches for Rare and Ultra-Rare Diseases

• Moderator: Tazeen Ahmad, Managing Director, Global Research, BofA Securities
• Demetrios Vavvas, MD, PhD, Associate Director of the Retina Service, Mass Eye and Ear; Solman and Libe Friedman Professor of Ophthalmology, Co-Director Ocular Regenerative Medical Institute, HMS

THE DR. IS IN | A New Hope: Cell Therapy and Transplantation for Parkinson’s Disease

• Moderator: Greg Harrison, Vice President, Global Research, BofA Securities
• Bob Carter, MD, PhD, Chairman, Department of Neurosurgery, MGH; William and Elizabeth Sweet Professor of Neurosurgery, HMS
• Todd Herrington, MD, PhD, Director, Deep Brain Stimulation Program, MGH; Assistant Professor of Neurology, HMS
• Kwang-Soo Kim, PhD, Director, Molecular Neurobiology Laboratory, McLean; Professor of Neuroscience and Psychiatry, HMS
• Jeffrey Schweitzer, MD, PhD, Neurosurgeon, MGH; Assistant Professor of Neurosurgery, HMS

THE DR. IS IN | The Inner Workings of Gene Therapy Manufacturing

• Moderator: Michael Ryskin, Director, Global Research, BofA Securities
• Sarah Nikiforow, MD, PhD, Medical Director, Cell Manipulation Core Facility, Technical Director, Immune Effector Cell Therapy Program, DFCI; Assistant Professor, HMS

THE DR. IS IN | The Road Ahead: Regulatory Challenges for Gene and Cell Therapy

• Moderator: Geoff Meacham, PhD, Managing Director, Global Research, BofA Securities
• Peter Marks, MD, PhD, Director, Center for Biologics Evaluation and Research, FDA

THE DR. IS IN | The Mysterious Dark Genome

• Moderator: Angela Shen, MD, Vice President, Strategic Innovation Leaders, Mass General Brigham Innovation
• Moderator: Richard Young, PhD, Professor, Whitehead Institute, MIT
• Rosana Kapeller, MD, PhD, Co-Founder, President & CEO, ROME Therapeutics
• Josh Mandel-Brehm, President & CEO, CAMP4 Therapeutics
• Amir Nashat, PhD, Managing Partner, Polaris Ventures
• Issi Rozen, Venture Partner, GV

Capital Formation | Shaping Innovation

• Moderator: Greg Butz, Managing Director, Head of Life Sciences Investment Banking, BofA Securities
• Moderator: Sumit Mukherjee, Managing Director & Head of Healthcare in Equity Capital Markets, BofA Securities
• Shelley Chu, MD, PhD, Partner, Lightspeed
• Stephen Knight, MD, President & Managing Partner, F-Prime Capital
• Adam Koppel, MD, PhD, Managing Director, Bain Capital Life Sciences
• Daniel Krizek, Portfolio Manager, Citadel

FIRESIDE | Ending Cancer as We Know It: The Game Changing Potential of GCT

• Moderator: Erin Harris, Chief Editor, Cell & Gene
• David Scadden, MD, Director, Center for Regenerative Medicine, MGH; Gerald and Darlene Jordan Professor of Medicine, HMS
• Norman Sharpless, MD, Former Director, National Cancer Institute

FIRESIDE | Vision and Execution: Curing Disease with Cell Therapies

• Moderator: Marcela Maus, MD, PhD, Director, Cellular Immunotherapy Program, Cancer Center, MGH
  Associate Professor, Medicine, HMS
• Moderator: Ravi Thadhani, MD, Chief Academic Officer, Mass General Brigham
• Carl June, MD, Richard W. Vague Professor in Immunotherapy, Director, Center for Cellular Immunotherapies, Director, Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine

GCT Development Centers | Academia’s Unique Contribution

• Moderator: Ravi Thadhani, MD, Chief Academic Officer, Mass General Brigham
• Carl June, MD, Richard W. Vague Professor in Immunotherapy, Director, Center for Cellular Immunotherapies, Director, Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine
• Maria Millan, MD, President & CEO, California Institute for Regenerative Medicine
• Richard Mulligan, PhD, Mallinckrodt Professor of Genetics, Emeritus, HMS; Executive Vice Chairman, Sana Biotechnology, Inc
• Norman Sharpless, MD, Former Director, National Cancer Institute

FIRESIDE | Marc Casper

• Moderator: Derik de Bruin, PhD, Managing Director, Global Research, BofA Securities
• Marc Casper, CEO, ThermoFisher

Gene and Cell Therapy | The World Speaks

• Moderator: Christine Fox, President, Novartis Gene Therapies
• Christopher Baum, MD, Chairman of the Board of Directors, Berlin Institute of Health at Charité (BIH)
• Nicholas Galakatos, PhD, Global Head of Life Sciences, Blackstone
• Luigi Naldini, MD, PhD, Director, San Raffaele Telethon Institute for Gene Therapy
• Kendra Rose, PhD, VP, Head of New Platforms, Ophthalmology and Hemophilia, Bayer

Control or Mitigation of the Effects of Chronic Neuroinflammation

The Cell Therapy Landscape | CAR-T to Stem Cells

• Moderator: Marcela Maus, MD, PhD, Director, Cellular Immunotherapy Program, Cancer Center, MGH; Associate Professor, Medicine, HMS
• Christina Coughlin, MD, PhD, CEO, CytoImmune
• Rachel Haurwitz, PhD, President & CEO, Caribou Biosciences
• Nick Leschly, CEO, 2seventy bio
• Dhvanit Shah, PhD, President & CEO, Garuda Therapeutics
• Rusty Williams, MD, PhD, Chairman & CEO, Walking Fish Therapeutics

Disrupting Interventions

• Introducer: John Fish, Chairman & CEO, Suffolk; Chair, Brigham and Women’s Hospital
• Moderator: Robert Higgins, MD, President, Brigham and Women’s Hospital; Executive Vice President, Mass General Brigham
• Irina Antonijevic, MD, PhD, CMO and Head of R&D, Triplet Therapeutics, Inc.
• Rachel McMinn, PhD, Founder & CEO, Neurogene
• Harith Rajagopalan, MD, PhD, CEO & Co-Founder, Fractyl Health
• Bastiano Sanna, PhD, EVP, Chief of Cell & Gene Therapies and VCGT Site Head, Vertex Pharmaceuticals
• Jeffrey Schweitzer, MD, PhD, Neurosurgeon, MGH; Assistant Professor of Neurosurgery, HMS

FIRESIDE | Reimagining GCT Production

• Moderator: Derik de Bruin, PhD, Managing Director, Global Research, BofA Securities
• Jason Kelly, PhD, Co-Founder & CEO, Ginkgo Bioworks

Gene and Cell Therapy Safety | Enduring Framework Required

• Moderator: Christine Seidman, MD, Director, Cardiovascular Genetics Center, BWH; Smith Professor of Medicine & Genetics, HMS
• Rick Fair, President & CEO, Bellicum
• Alexandria Forbes, PhD, President & CEO, MeiraGTx
• Sekar Kathiresan, MD, CEO, Verve Therapeutics
  Rick Modi, CEO, Affinia Therapeutics

RNA Therapeutics | Lessons Learned

• Moderator: Janet Wu, Anchor/Reporter, Bloomberg
• Sarah Boyce, President & CEO, Avidity Biosciences, Inc.
• Jim Burns, PhD, CEO, Locanabio
• Jeannie Lee, MD, PhD, Molecular Biologist, MGH; Professor of Genetics, HMS
• Laura Sepp-Lorenzino, PhD, Chief Scientific Officer, Executive Vice President, Intellia Therapeutics

Disruptive Dozen: 12 Technologies That Will Reinvent GCT in the Next Five Years

• Moderator: Nino Chiocca, MD, PhD, Neurosurgeon-in-Chief and Chairman, Neurosurgery, BWH; Harvey W. Cushing Professor of Neurosurgery, HMS
• Moderator: Susan Slaugenhaupt, PhD, Scientific Director and Elizabeth G. Riley and Daniel E. Smith Jr. Endowed Chair, Mass General Research Institute; Professor, Neurology, HMS
• Moderator: Ravi Thadhani, MD, Chief Academic Officer, Mass General Brigham
• Galit Alter, PhD, Principal Investigator, Ragon Institute, MGH; Professor of Medicine, HMS
• Natalie Artzi, PhD, Assistant Professor of Medicine, HMS
• Fengfeng Bei, PhD, Principal Investigator, Department of Neurosurgery, BWH; Assistant Professor of Neurosurgery, HMS
• Zheng-Yi Chen, DPhil, Associate Scientist, Eaton-Peabody Laboratories, Mass Eye and Ear; Associate Professor of Otolaryngology Head and Neck Surgery, HMS
• Matthew Frigault, MD, Clinical Director, Cellular Immunotherapy Program, MGH; Assistant Professor of Medicine, HMS
• Michael Gilmore, PhD, Chief Scientific Officer, Mass Eye and Ear; Sir William Osler Professor of Ophthalmology, HMS
• Allan Goldstein, MD, Chief of Pediatric Surgery, MGH; Surgeon-in-Chief, MassGeneral for Children
• Anna Krichevsky, PhD, Associate Professor of Neurology, BWH, HMS
• Jeannie Lee, MD, PhD, Molecular Biologist, MGH; Professor of Genetics, HMS
• James Markmann, MD, PhD, Chief, Division of Transplant Surgery, MGH; Claude E. Welch Professor of Surgery, HMS
• Khalid Shah, PhD, Vice Chairman of Research, Department of Neurosurgery, BWH; Professor, HMS
• Demetrios Vavvas, MD, PhD, Associate Director of the Retina Service, Mass Eye and Ear; Solman and Libe Friedman Professor of Ophthalmology, Co-Director Ocular Regenerative Medical Institute, HMS