Calum MacRae is a cardiologist, geneticist and developmental biologist who trained in Edinburgh, London and Boston. He is Chief of Cardiovascular Medicine at Brigham and Women’s Hospital and Associate Professor of Medicine at Harvard Medical School. He is also an Associate Member at the Broad Institute and a Principal Faculty Member at the Harvard Stem Cell Institute. His research is focused on understanding the fundamental mechanisms of disease using human studies and complementary efforts combining systems level modeling with empiric high-throughput biology in the zebrafish. His clinical interests include general cardiology, genomic medicine, innovation in phenotyping and the redesign of clinical care.