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Tanya Mayadas, PhD

Tanya Mayadas, PhD is a Professor of Pathology at Harvard Medical School and a Staff Scientist at the Brigham and Women’s Hospital. She received her PhD in Biochemistry from the University of Rochester, Rochester NY and completed a joint post-doctoral fellowship at Massachusetts Institutes of Technology and Tufts Medical Center, Boston MA before being appointed Assistant Professor of Pathology at Harvard in 1993. She is internationally recognized for her work in immune and vascular cell-mediated mechanisms of inflammation. She has established human neutrophil FcγRs (receptors for IgG) and associated signaling pathways as primary mediators of neutrophil recruitment and associated organ damage in IgG-mediated autoimmune diseases that affect the kidney. She has also made important discoveries linking renal TNF receptor 2 and downstream autocrine IFNβ signaling to damage associated with autoimmune mediated glomerular inflammation. Her recent work demonstrated that engagement of a specific FcγR on neutrophils with an antibody conjugated to a tumor expressed antigen induces the adaptive immune response and robust anti-tumor immunity. Understanding this process and the clinical implications of the results are a major focus of her current research efforts. Her work has been continuously funded by National Institutes of Health (NIH) since 1994 and she has served on several NIH study sections. Her scientific contributions have been recognized by a Young Investigator award by the Society of Leukocyte Biology, an American Heart Association Established Investigator Grant, the Stewart-Niewiarowski Award for Women in Vascular Biology and the Distinguished Innovator Award from the Lupus Research Institute.

Senior Staff Scientist, BWH;

Professor of Pathology, HMS

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