What if you could regenerate the gut’s nervous system with a simple cell therapy? In this episode of unNatural Selection, Dr. Allan Goldstein—Surgeon-in-Chief at Mass General for Children and Chief of Pediatric Surgery at Massachusetts General Hospital—discusses his work on neurosphere-based treatments for Hirschsprung disease. This novel approach could transform care not only for children with this rare condition, but also for millions suffering from broader gastrointestinal motility disorders. We explore the biology, the hurdles, and the future potential of rewiring the gut with living cells.