Discovery of effective antibiotics has been one of the hallmark achievements of modern medicine. Maladies that historically decimated populations have been mitigated if not eliminated through developments in diagnosing and treating infectious diseases. Partly due to the overuse of one of the mainstays of medical treatment, antibiotics, resistance to treatment is emerging and no immediate replacement appears to be available. This session will discuss the growing threat of antibiotic resistance and what scientific, clinical and policy approaches may help mitigate that threat.