Patricia Musolino MD, PhD is a critical care and vascular neurologist with expertise in genetics and cerebrovascular biology. Former Partners Neurology residency graduate she stayed at MGH for neurocritical care fellowship and she is currently junior faculty in the divisions of Neurocritical Care, Stroke and Child Neurology. She cares for patients in the Neuroscience Intensive Care Unit, the Emergency Department and is the Co-director of the Pediatric Stroke and Cerebrovascular Service. Dr. Musolino laboratory work focuses on leveraging insights from neuroimaging in patients and gene-editing tools applied to animal and in-vitro model systems to understand how single genes mutations alter blood brain barrier and cerebrovascular function in order to develop better treatments to improve the quality of life of patients with monogenic disorders.
Together with Dr. Jayashree Kalpathy and Bruce Rosen, Dr. Musolino has been levering deep learning algorithms to develop new technologies to improve diagnosis and treatments of patients with these devastating monogenic disorders. Her contributions have been published in high impact journals including NEJM, Brain, Jama Neurology and Neurology. She has successfully served as the principal investigator of clinical trials in stroke and as co-investigator in multiple trials including MS and gene-therapy for cerebral adrenoleukodystrophy and spinal muscular atrophy. Dr. Musolino’s work has received support from NINDS since 2010 through an R25, a K12 and a K08 Career Development Awards and had been recognized by several awards including the Hearst and Child Neurology Foundations, 2017 Herbert Pardes Clinical Research Excellence Award for the first gene therapy trial in a cerebral disorder.