Ole Isacson, MD, PhD - World Medical Innovation Forum
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Ole Isacson, MD, PhD

Director, Neuroregeneration Research Institute, McLean

Professor of Neurology & Neuroscience, HMS

Dr. Ole Isacson (MD-PhD) is Professor of Neurology (Neuroscience) at Harvard Medical School and the founding director of the Neuroregeneration Research Institute at McLean Hospital (MGB). After completion of his MD-PhD and research at University of Lund, Sweden, and a post doctoral fellowship at University of Cambridge, UK, Dr Isacson was recruited as faculty to Harvard University and Massachusetts General Hospital, Dept of Neurology, and McLean Hospital to establish an independent laboratory. Prof. Isacson’s laboratory has elucidated biological processes, mechanisms and treatments of neuronal vulnerability in several neurodegenerative diseases. To reverse the effects of brain cell death, his work has pioneered and patented new biotechnologies for restorative treatments using molecular, gene therapy and cell replacement methods, including stem cell derived patient derived neurons. Prof. Isacson’s studies are fundamental to many of the cell and stem cell applications now approaching clinical practice for Parkinson’s disease and other neurological disorders. The dual goals of his current work are to prevent brain degeneration in Parkinson’s and dementia related pathologies; and repair any irreversible brain damage by micro-restoration of new neurons and glia in the brain. Recently, he and his collaborators have found lysosomal and lipid function to be defective in Parkinson’s disease cells and tissues. New research in his laboratory have shown how to resolve lipid-induced problems in Parkinson’s disease and dementia pre-clinical animal models. In addition, he and his team have established models and published extensively on the nexus of inflammatory reactions and neurodegenerative diseases. Prof. Isacson is Principal Faculty of the Harvard Stem Cell Institute, since it was founded in 2005. He served as a member of the Michael J. Fox Foundation Executive Scientific Advisory Board (2014-2016). He has received several international prizes, research awards and lectureships, including The Royal Swedish Academy of Sciences: The Lindahl Investigator Award, the Bernard Sanberg Memorial Prize for Brain Repair, and the Stem Cell Innovator Award. Prof. Isacson served as the President of the International Cell Transplant Society (TTS), (2007-2008). In addition to his academic work, he served as a US government federal advisory committee member for the FDA Center for Biologics Evaluation and Research (CBER) (2014-2016) and the CSO of Pfizer’s Neuroscience Division (2016-2017). He is the author or co-author of ~ 400 scientific research articles and 3 books in his field. He was the Editor-in-Chief of the journal Molecular and Cellular Neuroscience from 2010-2016. Prof. Isacson was elected fellow of the American Association for the Advancement of Science (AAAS) in 2013.

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