Dr. Shah is the Vice Chairman of Research for the Department of Neurosurgery at BWH and Professor at Harvard Medical School. He directs the Center for Stem Cell and Translational Therapeutics and also a joint Center of Excellence in Biomedicine. He is also a Principal Faculty at Harvard Stem Cell Institute in Boston.
Dr. Shah and his team have pioneered major developments in the Cell therapy field, successfully developing experimental models to understand basic cancer biology and therapeutic stem cells for cancer. These studies have been published in a number of very high impact journals like Nature Neuroscience, PNAS, Nature Reviews Cancer, JNCI, Stem Cells and Lancet Oncology. Dr. Shah’s stem cell work has caught the attention in the public domain and as such it has been highlighted in the media world-wide including features on BBC and CNN. Recently, Dr. Shah’s laboratory has reverse engineered cancer cells using CRISPR/Cas9 technology and utilized them as therapeutics to treat cancer. This work was published in journal Science Translation Medicine and highlighted world-wide including features on Scientific American, New York Times and NPR. Amongst Dr. Shah’s published works are two books featuring groundbreaking insights into stem cell therapies for cancer, Stem Cell Therapeutics for Cancer (Wiley-Blackwell), and Mesenchymal Stem Cells in Cancer Therapy (Elsevier).
The potential of developing novel cancer therapies by him and his team has been recognized by many cancer alliances and associations. Based on this, he has received the young investigator award from Alliance for cancer gene therapy (ACGT), Research fellow award from American Cancer Society (ACS), Distinguished research award from Academy of Radiology and Innovation awards from James McDonnell Foundation, American Brain Tumor Association (ABTA) and Goldhirsh foundation. Recently he has received Department of Defense Idea and Impact awards for his work on treating metastatic brain tumors. Dr. Shah has often been invited to serve as a grant reviewer for the NIH and has reviewed applications to granting agencies in the US, Australia, and United Kingdom, such as the European Science Foundation, the Welcome Trust, the Samantha Dickson Brain Tumour Trust, and the California Institute of Regenerative Medicine. Additionally, Dr. Shah has participated in the training of numerous undergraduate, graduate students and residents who have come from across the US and from 40 foreign countries. He has also received many awards for his mentorship including Young Mentor Award from Harvard University.
Dr. Shah holds current positions on numerous councils, advisory and editorial boards in the fields of Cell therapy and Oncology. He has presented his findings for more than 300 academic seminars worldwide and in recent years has given various keynote lectures on Innovation and Translation of biological therapies. Dr. Shah currently holds more than 10 patents and he has founded two biotech companies whose main objective is the clinical translation of therapeutic cells in cancer patients.